Nature

Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/lpr mouse model of systemic lupus erythematosus

Despite findings suggesting a role for HSP90 in SLE, or the anti-inflammatory effects of HSP90 inhibition, little has been published exploring the effect of HSP90 inhibition in SLE. Based on the ...
Nature

PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus

Systemic lupus erythematosus (SLE) is a chronic inflammatory disease generated by deregulation of T cell–mediated B-cell activation, which results in glomerulonephritis and renal failure. Disease is ...
JSTOR Daily

Repeated 0.5-Gy Gamma Irradiation Attenuates Autoimmune Disease in MRL-Ipr/Ipr Mice with Suppression of CD3⁺CD4⁻CD8⁻B220⁺ T-Cell Proliferation and with Up-Regulation of ...

MRL-lpr/lpr mice are used as a model of systemic lupus erythematosus. We previously reported attenuation of autoimmune disease in MRL-lpr/lpr mice by repeated γ irradiation (0.5 Gy each time). In this ...
BBC Science/Nature

Mouse sheds light on regeneration

Hole closure is seen in MRL mouse (right), but not in the control (left) Regeneration - the ability to recreate lost or damaged cells, tissues, organs or even limbs - has a limited capacity in mammals ...