Mutations in the tumor suppressor TP53 are a common cause of cancer, making the altered protein an attractive target for therapeutics. Among them, the Y220C mutation is the ninth most frequent and it ...

What is TP53 and what role does it play in cancer? Medically reviewed by Marla Anderson, MD The TP53 gene helps prevent cancer by repairing DNA or causing cell death when DNA is too damaged. Mutations ...

Geneticists from KU Leuven, Belgium, have shown that tumour protein TP53 knows exactly where to bind to our DNA to prevent cancer. Once bound to this specific DNA sequence, the protein can activate ...