On Target is a new recurring feature from STAT that dives deep into the most promising drug targets in oncology. Of all the wily ways tumors have to turn back attacks from therapies or the immune ...

When it comes to cancer metastasis, it takes two to tango. That was one of the key findings of a new study led by researchers at Memorial Sloan Kettering Cancer Center (MSK): The TGF-beta and RAS ...

Investigating the association of WNT pathway dysregulation and young-onset colorectal cancer. This is an ASCO Meeting Abstract from the 2024 ASCO Gastrointestinal Cancers Symposium. This abstract does ...

Role of Transforming Growth Factor Beta in Human Cancer . If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select ...

A working model showing that CAFs exhibit profound amino acid reprogramming, especially the production of glycine, in CRC. CRC cell‐derived TGF‐β1 activates de novo glycine synthesis in CAFs, ...

For years, scientists have thought that TGF-Beta, a signaling protein that holds sway over an astonishing array of cellular processes from embryonic development to cancer, could only do its work once ...