Researchers have engineered a next-generation glutamate sensor, iGluSnFR4, capable of detecting the faintest incoming ...

A new protein sensor lets researchers see incoming brain signals, revealing how neurons process information tied to memory ...

Increased levels of bioactive lipids produced naturally in the body, which affect excitatory transmission between brain cells, promote mental disorders. However, this mechanism can be rebalanced by ...

Singapore has one of the highest life expectancies in the world, yet many individuals spend almost a decade in poor health ...

Ketamine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist that produces rapid antidepressant action in some patients with treatment-resistant depression. However, recent data ...

Parkinson's and Alzheimer's diseases are the two most common neurodegenerative disorders, affecting millions of people worldwide. Published in the Journal of Neuroscience, new research from the ...

The tongue contains numerous taste buds—tiny sensory organs responsible for detecting taste. Taste buds consist of specialized cells that translate chemical stimuli into neural signals. Among them, ...

The rapid influx of cerebral spinal fluid (CSF) and protein solutes released during cortical spreading depression (CSD) in the brain activates neurons to trigger aural migraine headaches, according to ...

Neurons intertwine with small blood vessels in the brain, but how do the two communicate? With elaborate three-dimensional reconstructions of electron microscopy images, scientists led by Jie-Min Jia, ...

A) Taste tissue of wild-type mice and taste cell synaptic dysfunction mice (SNAP-cKO). In SNAP-cKO mice, the number of sour-sensing cells is reduced. B) Gustatory nerve responses to various taste ...