Relapse isn’t a failure. It’s a signal. It tells us that something deeper is still driving our old behaviors. For decades, I’ve studied the science of addiction, relapse, and behavior change through ...

Research on the biological basis of addiction has found that the critical epigenetic enzyme histone deacetylase 5 (HDAC5) limits the expression of the gene Scn4b, regulating neuronal activity and ...

Drug addiction is a chronic, often relapsing disorder that affects millions of people worldwide. Despite successful treatment, many individuals struggle to maintain sobriety and may relapse.

As you recover from an opioid use disorder, it’s harder on some days than others to avoid using. In fact, 40% to 60% of people with substance abuse disorder (SUD) have a relapse at some point. To keep ...

Learn about common triggers for depression relapse. Major depressive disorderis typically not a one-and-done type of condition. Many people with depression who have been treated and experienced some ...

For hundreds of years, craving has been recognized as a central causal feature of addiction and relapse in overeating, gambling, and other addictions. But what causes craving, how one ends cravings, ...

Every experience leaves a trace in the brain, a memory that can shape future behavior. Alcohol and other addictive substances ...

Research on the biological basis of addiction published in Biological Psychiatry uncovers the critical role that the HDAC5 enzyme plays in gene expression in the brain's epigenetic mechanisms that ...