Morning Overview on MSN

RNA strand that nearly self-replicates could unlock life’s origin

A 45-nucleotide strand of RNA can now synthesize both its mirror-image complement and a copy of itself, bringing scientists ...
New Atlas

Mice have innate gene therapy agent to sidestep mutations, study finds

Researchers have discovered that mice possess a natural form of gene therapy, a non-coding RNA that can sidestep genetic mutations. They were able to engineer a programmable version that recognized ...

Tiny one- to three-base RNAs could help stop autoimmune inflammation, study suggests

RNA-based medicine is about to take a huge leap forward thanks to the discovery of extremely short RNA fragments with ...
News Medical

Non-coding RNA mutations unveiled as new cause of retinitis pigmentosa

Retinitis pigmentosa (RP) is a genetic eye disorder affecting around one in 5,000 people worldwide. It typically begins with night blindness in youth and progresses to tunnel vision as ...
Technology Networks

Cells Use mRNA Fragments To Activate Backup Genes

Researchers uncovered how cells coordinate genetic compensation when faulty mRNA is degraded. Small RNA fragments act as sequence “addresses” that recruit ILF3 to activate related backup genes.

Tiny, 45 base long RNA can make copies of itself

These random molecules were fed a collection of three-base-long RNAs, each linked to a chemical tag. The idea was that if a molecule is capable of ligating one of these short RNA fragments to itself, ...
ascopubs.org

Survey of actionable driver mutations KRAS and EGFR in non–small cell lung cancer to evaluate coexisting splicing gene and pathway mutations: A CBioportal database analysis.

Five-year outcomes with first-line (1L) nivolumab + ipilimumab + chemotherapy (N + I + C) vs C in patients (pts) with metastatic NSCLC (mNSCLC) in CheckMate 9LA. Co-occurring RNA splicing alterations ...

mRNA fragments reveal a hidden process that protects cells from harmful mutations

Some genetic mutations that are expected to completely stop a gene from working surprisingly cause only mild or even no symptoms. Researchers in previous studies have discovered one reason why: cells ...
Forbes

Mutations In Newly Discovered Microproteins Are Changing Our Understanding Of Human Disease

Thousands of previously “invisible” microproteins—tiny chains of fewer than 100 amino acids—can profoundly change human biology when mutated. A fundamental discovery is overturning decades of ...
technologynetworks

Mutations Affecting RNA Splicing Contribute to Rare Blood Cancer

Mount Sinai and UC San Diego researchers have shown for the first time how mutations affecting a cellular process called RNA splicing alter cells to develop myelodysplastic syndrome (MDS) and other ...