p21 came into the spotlight as a mediator of p53 tumour suppressor activity and as an inhibitor of cell cycle progression owing to its ability to inhibit the activity of cyclin-dependent kinase ...

Cell cycle regulation balances the requirement of proliferation during tissue growth and homeostasis, with the need to ensure that damaged DNA is not propagated to future generations. Checkpoints have ...

New research at Rice University is allowing biochemists to understand a key hierarchy of protein interactions that occurs in DNA replication, showing for the first time how a key protein ...