Spontaneous mutations tend to reduce fitness in populations of living organisms, but this erosion of fitness is countered by natural selection. This study uses the first mutation accumulation ...

Mutations in LXRα lead to liver cholesterol buildup, hepatitis, and fibrosis in individuals on a Western diet, highlighting the receptor's role in maintaining liver health. Study: Damaging mutations ...

Two new studies from Karolinska Institutet in Sweden have investigated how mutations that occur in muscles and blood vessels over time can affect ageing. The studies, which are published in Nature ...

Biological aging undeniably affects human cognitive function. 1 However, how this happens—the underlying factors, interactions, and processes—remains unclear. He and his team want to understand how ...