Allergic inflammation arises when innate immune cells detect harmless environmental antigens and mount a type-2 biased response that can culminate in tissue pathology. Key effector cells—mast cells, ...

The innate immune system is the body's first line of defense against pathogens and foreign substances. An essential component of this system are pattern recognition receptors, which recognize non-self ...

Secondary infections caused by bacteria or viruses during hospital care remain a long-standing global challenge, despite advances in modern medicine. In particular, mixed bacterial–viral infections in ...

We sometimes hear about the benefits of “boosting” our immune system, but what we really want to do is support our immune system on an ongoing basis. People often think of the immune system as ...

Three G protein–coupled receptors, the cysteinyl leukotriene receptors 1, 2, and 3 (CysLTR1, CysLTR2, and CysLTR3), mediate the effects of the cysteinyl leukotrienes in vivo. (Each receptor has a ...

In several disease conditions, including infections and cancers, innate immune activation and nutrient scarcity occur together. A study from St. Jude Children's Research Hospital published today in ...

Dozens of new discoveries reveal that defenses evolved by bacteria and viruses billions of years ago still define our own innate immune system. Evolutionary arms races — where one species is pitted ...