Findings from a preclinical study demonstrate that Omomyc—the only direct MYC inhibitor to have successfully completed a phase I clinical trial—causes DNA damage in cancer cells which is ...

Please provide your email address to receive an email when new articles are posted on . Inhibiting RMB42 disrupted production of Myc proteins in pancreatic cancer cells. This approach could curtail ...

Unless otherwise listed, all solvents and reagents were purchased from Aldrich Chemical Co. (MO, USA) and used as received. Anhydrous chloroform and methanol were purchased from Aldrich Chemical Co.

Richter transformation develops in 2%–10% of CLL cases, often with rapid clinical decline, limited chemotherapy efficacy, and ...

Sarki Abdulkadir, MD, PhD, John T. Grayhack Professor of Urologic Research and director of the Center for Urologic Oncology at the Feinberg School of Medicine For decades, researchers have known that ...

Treatment schedule in an immunocompetent mouse model bearing a high burden of Burkitt’s lymphoma. While conventional CAR-T therapy alone resulted in no cures, adding five doses of a SUMOylation ...