Reconstitution of the activation of the MLH1–MLH3 endonuclease shows how crossovers are formed during meiosis. When DNA breaks, cells use the homologous recombination pathway to accurately repair the ...
DNA interstrand crosslinks (ICLs) are highly cytotoxic lesions formed by covalent bonding between opposite DNA strands, obstructing essential processes such as replication and transcription. Repair of ...
When DNA breaks, cells must repair it accurately to prevent harmful mutations. Researchers have discovered that during a key repair process called homologous recombination, the cell uses loops in its ...
DNA replication proceeds through specialised structures known as replication forks, where parental duplex DNA is unwound and copied. The faithful progression and stability of these forks are essential ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results