Antisense oligonucleotides (ASOs) are small, single-stranded molecules that can suppress the expression of targeted genes and thereby achieve therapeutic effects. However, many ASO-based drug ...

Heteroduplex oligonucleotide (HDO) is a brand new oligonucleotide drug, pioneered by researchers of Tokyo Medical and Dental University, Osaka University and ISIS. HDO is found to be significantly ...

Researchers have developed a drug delivery platform wherein heteroduplex oligonucleotide drugs conjugated with cholesterol are able to cross the blood-brain barrier and achieve therapeutic ...

This study was approved by the Institutional Review Board of Kanagawa Cancer Center. Cytology specimens obtained by transbronchial abrasion were used for the analysis of EGFR gene mutations. All EGFR ...

Heteroduplex oligonucleotide is a brand new oligonucleotide drug. It is found to be significantly potent at reducing expression of the target RNA, and also improves the phenotype in disease models ...

Researchers from Tokyo Medical and Dental University (TMDU), Takeda Pharmaceutical Co., Ltd. and Ionis Pharmaceuticals, USA, show that heteroduplex oligonucleotide drugs conjugated with cholesterol ...