In the ever changing biotherapeutics landscape, antibody-drug conjugates (ADCs) and monoclonal antibodies (mAbs) success hinges on more than simply antigen recognition. While the Fab region controls ...

The lower hinge of immunoglobulin G (IgG), an overlooked part of the antibody, acts as a structural and functional control hub, according to a study by researchers at Science Tokyo. Deleting a single ...

Deleting a single amino acid (Pro230) in the lower hinge produced half-IgG1 molecules with disrupted disulfide bonds and reoriented Fab and Fc regions, highlighting the hinge’s essential role in ...

Monoclonal antibodies are widely used to treat diseases ranging from cancer to autoimmune disorders. The safety and efficacy of these biologic drugs depend on maintaining their correct ...