The constitutively active, truncated epidermal growth factor receptor EGFRvIII lacks the ability of EGF binding due to a deletion of the NH 2-terminal domain. EGFRvIII confers increased tumorigenicity ...
In the U87MG glioma cell line in vitro, EGFRvIII enhances its antitumor activity by transactivating the hepatocyte growth factor (HGF) receptor (MET), AXL, platelet-derived growth factor receptor-β ...
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