Kanazawa University, in collaboration with Osaka University and the National Institutes for Quantum Science and Technology, ...

Cell surface receptors, such as the G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK), play central roles signalling pathways. Due to their central role in regulating a wide range ...

Although class A G protein–coupled receptors (GPCRs) can function as monomers, many of them form dimers and oligomers, but the mechanisms and functional relevance of such oligomerization is ill ...

As a physiological regulator of bile acid homeostasis, FGF19 is also a potent insulin sensitizer capable of normalizing plasma glucose concentration, improving lipid profile, ameliorating fatty liver ...

Receptor tyrosine kinases are a large family of cell-surface receptors that respond to a variety of intercellular signals, including insulin, growth factors such as epidermal growth factor (EGF) and ...

A dream drug would provide a targeted therapeutic effect without side effects. Biased signalling, whereby certain cellular signalling pathways are favoured over others, could make this a reality. Now, ...