The much-heralded Human Genome Project was a huge milestone for science, but most of that genetic blueprint came from one man from Buffalo, N.Y. On Wednesday, May 10, 2023, scientists announced they ...

Some sequences in the genome cause genes to be switched on or off. Until now, each of these gene switches, or so-called enhancers, was thought to have its own place on the DNA. Different enhancers are ...

An international team, including researchers from HSE University, has created the first comprehensive map of ...

Scientists have created the first comprehensive map of DNA quadruplexes, fleeting knot-like structures that play an outsized ...

Researchers have identified elusive DNA switches in brain support cells that influence genes tied to Alzheimer’s disease. When people think about DNA, they often picture genes that determine our ...

In mammalian genome, enhancers are sequences that are often far away from their target genes. They play a key role in transcription regulation through long-range DNA loops. It is now widely accepted ...

Figure 1: KMAP visualisation of SELEX-seq data for the transcription factor MAFK. Each dot represents a k-mer. Clusters of k-mers at the center correspond to DNA motifs, while the surrounding dots ...

Despite spanning about three billion base pairs, the human genome is wrapped up tight in a highly organized fashion in the nucleus. This coordinated structure, in part, enables the cell to regulate ...

A new study shows, for the first time, how the human genome folds and moves in 3D over time to control when genes turn on and ...

Researchers have revealed a new mechanism underlying how spatial distance between specific regions of DNA is linked to bursts of gene activity. Using advanced cell imaging techniques and computer ...