Electron tomography is a powerful imaging technique that enables the three-dimensional (3D) visualization and analysis of nanostructures at the atomic scale. By combining advanced electron microscopy ...

Recent progress in cryo-electron tomography (cryo-ET) has made it practical to look at macromolecular machines inside intact cells. On the instrumentation side, detector, energy filters, and cryo-FIB ...

Cryo-electron tomography enabled the researchers to show the spatial organization of proteins and unveiled a persistent association between V-ATPase and synaptophysin, suggesting that the interaction ...

Research has demonstrated that actin waves propagate via actin polymerization on the substrate-attached cell membrane at the wave’s front and disassembly at the back of the wave. 4 Proteins named Arp2 ...

Scientists investigating Alzheimer's disease have determined the structure of molecules within a human brain for the very first time. This gave 3-dimensional maps in which they could observe proteins, ...

Biochemist Wolfgang Baumeister, director emeritus of the Max Planck Institute of Biochemistry, has received the 2025 Shaw Prize in Life Science and Medicine. The Shaw Prizes have been awarded annually ...

In this episode of C&EN Uncovered, host Craig Bettenhausen speaks with C&EN senior editor Laurel Oldach about a laser phase ...

Cryo-electron microscopy (cryo-EM) can help scientists determine the three-dimensional structure of proteins in unprecedented detail. Jacques Dubochet, former group leader at EMBL, shared the 2017 ...

In this useful Tools & Resources article, the authors describe a new cryogenic light microscopy design and characterize its temperature and spatial stability. This compelling system avoids the ...

Cryo-electron microscopy (cryo-EM) has revolutionalized our understanding of the intricate molecular machinery that governs life. It has elucidated the three-dimensional (3D) structure of biological ...