In a recent study published in the journal Nature, researchers identify the mechanisms through which double-stranded break (DSB)-induced compartment formation orchestrates the deoxyribonucleic acid ...

Cars patched up after a wreck may look fixed—but never run quite as before. The same may hold true for chromatin, according to a study published in Science on November 6. In response to double-strand ...

Chromatin remodelers are ATP-dependent motor proteins that dynamically reorganize chromatin architecture, playing essential roles in gene expression, development, and immune function. Dysregulation of ...

Originally isolated from soil microbes, “anthracyclines rapidly made their way to the clinic and are still one of the most effective compounds we have today,” explained Dr. Matthew Wooten, a ...

Researchers at the RIKEN Center for Biosystems Dynamics Research (BDR) have identified key changes to both chromosome structure and gene expression that affect stem cell function during aging. Using ...

DNA inside human cells is not free-floating. Instead, it is tightly wrapped around small protein units forming a long chain, with DNA looping around each unit before moving on to the next. This ...

Among the many marvels of life is the cell's ability to divide and thus enable organisms to grow and renew themselves. For this, the cell must duplicate its DNA – its genome – and segregate it equally ...

The researchers found that, contrary to how it’s depicted in most textbooks, chromatin does not fold in on itself in an organized manner to create distinct structures. Instead, it forms a pliable, ...

Complementary value of a digital pathology biomarker to post-surgery circulating tumor DNA in risk stratification of stage III colon cancer patients receiving adjuvant chemotherapy. This is an ASCO ...