Researchers at the University of Pennsylvania School of Veterinary Medicine have demonstrated the potential of a new strategy for genetic modification of large animals. The method employs a harmless ...

A new strategy for genetic modification of large animals by employing a virus that transfers genetic modifications to male reproductive cells, which passes naturally to offspring has been developed.

Two general strategies are being developed to engineer mammalian artificial chromosomes (MACs) as therapeutic vectors: (1) in vitro MAC cloning by enzymatic ligation of the individual MAC components ...

Visit NAP.edu/10766 to get more information about this book, to buy it in print, or to download it as a free PDF. With a growing human population and rising living standards, demand for animal-derived ...

CRISPR-Cas technology has radically changed how transgenic models are created. Through CRISPR approaches, researchers have pioneered how to create complex animal models, including long cassette ...