Cyclic peptides often exhibit low membrane permeability which can be significantly improved via amide-to-ester substitutions—as demonstrated by researchers from Tokyo Institute of Technology (Tokyo ...

The amide bond is one of nature’s most common functional and structural elements, as the backbones of all natural peptides and proteins are composed of amide bonds. Amides are also present in many ...

A new reaction that uses an atypical starting material to create amide linkages could make it easier to prepare peptides and other amide-containing compounds that have been difficult to make until now ...