JSTOR Daily

ATP-Dependent Degradation of a Mutant Serine:Pyruvate/Alanine:Glyoxylate Aminotransferase in a Primary Hyperoxaluria Type 1 Case

Primary hyperoxaluria type 1 (PH 1), an inborn error of glyoxylate metabolism characterized by excessive synthesis of oxalate and glycolate, is caused by a defect in ...
Nature

416 Cerebral Alanine Increases During the Evolution of Secondary Energy Failure Following Transient Hypoxia-Ischaemia in Newborn Brain

Background: Alanine (Ala), a nonessential amino acid, is present in normal brain at a concentration of ∼0.5 mmol/kg. During acute hypoxia-ischaemia (HI) Ala increases due to decreased flux of pyruvate ...
eLife

The fate of pyruvate dictates cell growth by modulating cellular redox potential

Pyruvate dictates redox balance and cell size, establishing metabolism as a dominant regulator of cellular fitness, unveiling new strategies to modulate cancer, regeneration, and diabetes.
JSTOR Daily

Characterization of alanine aminotransferase (AlaAT) multigene family and hypoxic response in young seedlings of the model legume Medicago truncatula

Journal of Experimental Botany, Vol. 57, No. 12 (2006), pp. 3079-3089 (11 pages) Four alanine aminotransferases (AlaATs) are expressed in Medicago truncatula. In adult plants, two genes encoding ...