On April 14, 2003, the National Institutes of Health issued a press release announcing that the Human Genome Project had been completed ahead of schedule and under budget. At the time, the human ...

Sequence-based protein function and structure prediction depends crucially on sequence-search sensitivity and accuracy of the resulting sequence alignments. We present an open-source, general-purpose ...

In the past 50 years, there has been tremendous progress in experimental determination of protein three-dimensional structures, but this has not kept pace with the explosive growth of sequence ...

CRISPR technology has revolutionized life sciences research and drug development. Still a young technology albeit incredibly powerful, ongoing advances are providing better tools to increase the pace ...